Regeneration in musculoskeletal tissue
A stem cell is a cell able to divide for indefinite periods – often for the entire life of an organism. Stem cells, adequately stimulated by “signaling” factor,s have the potential to differentiate into different cell types. These differentiated cells of mesenchymal origin have shape and specialized functions, giving rise to muscle tissue, bone, cartilage, tendon, etc…
The use of mesenchymal stem cells in orthopedics has gained strong momentum in recent years and now represents the fastest-growing area of research and clinical application.
The stem cells used for regeneration more skeletal muscle stem cells are mesenchymal adult: is an undifferentiated cell that is located in a differentiated tissue, can renew itself and become specialized to produce all the specialized cell types of the tissue from which it originated. Sources of adult stem cells have been found in bone marrow, blood, cornea and retina of the eye, dental pulp, liver, skin, pancreas, and especially in adipose tissue.
Clinical applications in orthopedics:
1) Regeneration spinal cord
2) critical bone defects and nonunions
3) Repair cartilage
4) Regeneration of the anterior cruciate ligament and meniscus.
5) Muscular Dystrophies
6) Spinal Fusion
7) Degeneration of the intervertebral disc